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First, how should it handle certain diseases, which appear to be etiologically more complex than the infections and deficiencies by which epidemiology made its name?In particular, chronic non-communicable diseases (CNCDs) account for a larger proportion of deaths, at least in the … Introduction. Web of causation models are especially helpful for finding the causes of genetic diseases. First articulated in a 1960 U.S. epidemiology textbook, the 'web' remains a widely accepted but poorly elaborated model, reflecting in part the contemporary stress on epidemiologic methods over epidemiologic theories of disease causation. Outside the context of infectious diseases, systematic use of diagrams in epidemiology has been mainly confined to the analysis of a single link: that between a disease outcome and its proximal determinant(s). It also brings genetics into the mix. Transmitted causes ("causes of causes") tend not to be systematically analysed. The wheel of causation, an alternative model, according to Harkness and DeMarco (2012), “…de-emphasizes the agent as the sole cause of disease, whereas it emphasizes the interplay of physical, biological, and social environments” (p.94). **This model explains multifactorial etiology of chronis diseases and how it is interrelated. Two conceptual questions currently face epidemiology, both relating to causation. Theories of causation • Old theories • Modern theories – germ theory – multifactorial causation – socioeconomic, cultural, genetic, psychological – epidemiological triad (tetrad) – web of causation – wheel of causation 6First MBBS – Epidemiology series 7. Several theories were advanced from time to time to explain disease causation such as the supernatural theory of disease, the theory of humors by Greeks and Indians, the theory of contagion, the miasmatic theory which attributed disease to noxious air and vapours, the theory of spontaneous generation, etc. ** The Wheel of Causation The Wheel of Causation (Mausner & Kramer, 1985) de-emphasizes the agent as the sole cause of disease, while emphasizing the interplay of physical, biological and social environments (Figure 7). ... causation is the theory that something happened due to a given cause. Cause and effect basically. For long, man was groping in darkness about the causation of disease. Alzheimer’s disease will be the epidemic of the twenty-first century (1,2). The wheel consists of a hub that represents the host and its human characteristics such as genetic makeup, personality, and immunity. The wheel allows for a multiple-causation theory of disease, it is more useful for analyzing complex chronic conditions. Figure 0: The Wheel of Causation One application of The Wheel of Causation Methods of diagrammatic modelling have been greatly developed in the past two decades. The generally accepted figures are that 5% of individuals of the age of 65 have severe dementia, and another 10% have moderate dementia, with 30% having developed dementia if they live to the age of 90. When the cause is determined, medical professionals learn more about which groups of people are prone to developing or contracting a certain disease. 'Multiple causation' is the canon of contemporary epidemiology, and its metaphor and model is the 'web of causation.' 1. the wheel of causation de emphasizes the agent as the sole cause of disease. The purpose is to identify risk factors that can be modified. Models of Disease Causation, Germ Theory, Epidemiological Triad, Web and Wheel of Disease Causation. 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